YC-1 induces lipid droplet formation in RAW 264.7 macrophages
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چکیده
منابع مشابه
Structure elucidation of fungal beauveriolide III, a novel inhibitor of lipid droplet formation in mouse macrophages.
The structure of fungal beauveriolide III, an inhibitor of lipid droplet formation in mouse macrophages, was elucidated to be cyclo-[(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl-L-alanyl- D-allo-isoleucyl] by spectral analyses and chemical degradation.
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The structures of phenochalasins A and B were elucidated by spectroscopic studies including various NMR measurements. Phenochalasins A and B have the cytochalasan skeleton of the 21,23-dioxa, 17,22-dione moiety containing unique phenyl and O-methyl phenyl residues at the C-10 position, respectively.
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Effects of seven cytochalasans including cytochalasins B, D and E and novel phenochalasins A and B were tested on cytosolic lipid droplet formation and neutral lipid synthesis in mouse peritoneal macrophages. Phenochalasin A inhibited lipid droplet formation in a dose-dependent manner at least up to 20 microM without any morphological changes in macrophages. Cytochalasins D and E also inhibited...
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The classical regard of lipid droplets as mere static energy-storage organelles has evolved dramatically. Nowadays these organelles are known to participate in key processes of cell homeostasis, and their abnormal regulation is linked to several disorders including metabolic diseases (diabetes, obesity, atherosclerosis or hepatic steatosis), inflammatory responses in leukocytes, cancer developm...
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Proteolysis in eukaryotic cells can be separated into two major pathways: one is mediated by the ubiquitin-proteasome system and by the autophagy-lysosome system. Substrates of lysosomes may be taken through heterophagocytosis, endocytosis, or autophagy into heterophagosomes, early endosomes, or autophagosomes, which receive lysosomal enzymes via transporting vesicles from the trans-Golgi netwo...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2016
ISSN: 1423-0127
DOI: 10.1186/s12929-016-0218-7